Antiviral compounds
AssigneesPace University, Research Foundation of The City of New York, Long Island University
InventorsRobert Engel, JaimeLee Iolani Rizzo, Karin Melkonian Fincher
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Abstract
The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.
Claims2
A method for protecting a surface from viral contamination, the method comprising converting the surface to an antiviral surface having the formula (I):
- wherein:
- SS represents a solid, macro surface comprising polymeric molecules having more than one primary hydroxyl group;
- n represents an integer from 2-8;
- Y represents —NR2, —+NR3, —PR2, —+PR3, —OH, —SH, —SR, —+SR2, —SO3 −, —SO2—OR, —OR, —C(O)R, —C(O)OR, or a diazabicyclo[2.2.2]octane derivative selected from:
- R independently represents H, C1-4 alkyl, or phenyl;
- R1 represents H, C1-4 alkyl, phenyl, —NR2, —PR2, —+PR3, —OH, —SH, —SR, —+SR2, —SO3−, —OR, —C(O)R, —C(O)OR, or —SO2—OR;
- B represents an anion;
- a represents an integer;
- c represents the valence of B, and is equal to 1-3;
- wherein a×c represents a number such that the compound is charge balanced;
- and
- with the proviso that the macro surface is not α-cyclodextrin or β-cyclodextrin.
A method for protecting a polymeric material from viral contamination, the method comprising converting the polymeric material to a solid antiviral composition comprising
- a) a polymeric material that is solid at room temperature and molten at elevated temperatures and, embedded therein;
- b) a compound of formula (II):
- Y—(CH2)n—X—Z—[X—(CH2)n—Y]m aB−c (II)
- wherein:
- Z represents a modified polyol having more than one primary hydroxyl group in the unmodified state, wherein at least two of the primary hydroxyl groups have been replaced by X—(CH2)n—Y groups;
- X represents
- n independently represents an integer from 2-8;
- Y represents —NR2, —+NR3, —PR2, —+PR3, —OH, —SH, —SR, —+SR2, —SO3−, —SO2—OR, —OR, —C(O)R, —C(O)OR, or a diazabicyclo [2.2.2] octane derivative selected from:
- R independently represents H, C1-4 alkyl, or phenyl;
- R1 represents H, C1-4 alkyl, phenyl, —NR2, —PR2, —+PR3, —OH, —SH, —SR, —+SR2, —SO3−, —OR, —C(O)R, —C(O)OR, or —SO2—OR;
- m represents any number up to m1−1 wherein m1 represents the number of primary hydroxyl groups in the polyol in the unmodified state;
- B represents an anion;
- a represents an integer;
- and
- c represents the valence of B, and is equal to 1-3;
- wherein a×c represents a number such that the compound is charge balanced.
Dependencies are inferred from the claim text.