Technique for drug and gene delivery to the cell cytosol
AssigneeBrigham Young University
InventorsWilliam G. Pitt, Ghaleb Husseini
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Abstract
Provided herein is a composition, a method, and a system for delivering a functional molecule to the cytosol of a cell, comprising a liposome configured to be taken into a cell, including by a process selected from the group consisting of endocytosis, pinocytosis or phagocytosis, the liposome comprising a phase transforming liquid with vapor pressure capable of forming a gas at low pressure, said liquid being associated with the liposome, and the liposome further comprising at least one functional molecule selected from the group consisting of a therapeutic molecule, a detectable label, and a targeting molecule.
Claims20
A composition comprising:
- a. a liposome configured to at least one of be taken into a cell, attach to a cell surface, and accumulate in a cell vicinity;
- b. a nanodroplet of a phase transforming liquid at least one of contained inside the liposome, within the liposome membrane, and attached to the exterior of the liposome, the phase transforming liquid being immiscible in water and the composition comprising a two phase aqueous/non-aqueous nanoemulsion, the phase transforming liquid having a vapor pressure capable of forming a gas at low pressure and the nanodroplet being configured to remain liquid above the normal boiling point of the phase transforming liquid and further configured to remain liquid after administration to a patient until activated by a decrease in pressure;
- and
- c. at least one functional molecule selected from the group consisting of a therapeutic molecule, a detectable label, and a targeting molecule, said functional molecule encapsulated by the liposome, within the lipid bilayer, or attached to the surface of the bilayer.
Dependencies are inferred from the claim text.