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US 8,999,290 B2Granted
Papillomavirus pseudoviruses for detection and therapy of tumors
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsJeff Roberts, Douglas R. Lowy, John T. Schiller
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Abstract
Disclosed herein are methods of detecting tumors, monitoring cancer therapy, and selectively inhibiting the proliferation and/or killing of cancer cells utilizing a papilloma pseudovirus or a papilloma virus-like particle (VLP).
Claims20
A method for detecting the presence of cancer cells bound to a papilloma pseudovirus or a papilloma VLP comprising:
- identifying a subject having or suspected of having cancer cells;
- administering to said subject a detectable amount of a papilloma pseudovirus or a papilloma VLP that comprises a detectable label;
- and
- detecting the presence of cancer cells bound to said papilloma pseudovirus or said papilloma VLP that comprises a detectable label.
1 more element
A method for evaluating a cancer therapy comprising:
- identifying a subject with a cancer;
- providing said subject a cancer therapy;
- administering to said subject a detectable amount of a papilloma pseudovirus or papilloma VLP that comprises a detectable label;
- and
- determining the presence or amount of said pseudovirus or said VLP bound to cancer cells in said subject, before a treatment with said cancer therapy and during or after a period of said treatment.
2 more elements
A method for detecting the presence of cervical cancer in a subject, comprising:
- providing to said subject a composition comprising a papilloma VLP coupled to or containing a detectable label;
- removing unbound VLPs that comprise the detectable label;
- and
- detecting the presence of cancer cells bound to said VLP that comprises the detectable label.
1 more element
Dependencies are inferred from the claim text.