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AssigneesPresident and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
InventorsKenneth C. Anderson, James E. Bradner, Edward Franklin Greenberg, Teru Hideshima, Nicholas Paul Kwiatkowski, Ralph Mazitschek, Stuart L. Schreiber, Jared Shaw, Stephen J. Haggarty
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The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.
A method of treating a subject suffering from or susceptible to cancer comprising administering to a subject in need thereof a therapeutically effective amount of a proteasome inhibitor and an aggresome inhibitor, wherein the aggresome inhibitor selectively inhibits HDAC6.
A method of treating a cell exhibiting symptoms of cancer comprising administering a therapeutically effective amount of a proteasome inhibitor and an aggresome inhibitor to the cell, wherein the aggresome inhibitor selectively inhibits HDAC6.
A method of treating a subject suffering from or susceptible to cancer comprising administering to a subject in need thereof a therapeutically effective amount of a proteasome inhibitor and an aggresome inhibitor, wherein the aggresome inhibitor is one of the formulae:
A method of inhibiting protein degradation in a cell comprising contacting the cell with a proteasome inhibitor and an aggresome inhibitor, wherein the aggresome inhibitor selectively inhibits HDAC6.
Dependencies are inferred from the claim text.