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US 8,999,001 B2Granted
Biocompatible implant
AssigneeAo Technology AG
InventorsMauro Alini, Sophie Verrier, David Olivier Eglin
Life of this patent
Estimating the term…
Abstract
A biocompatible implant for bone repair comprising a flexible membrane fitted around a bone defect and a platelet-rich plasma gel composition contained within the void space created by the membrane, its application and kit of parts thereof are described.
Claims19
A biocompatible implant for repair of a bone defect which comprises:
- (a) a flexible membrane comprising a biocompatible material having an inner and an outer surface capable of being fitted around said bone defect to create an enclosed void space, said membrane being seeded with autologous cells on one or both surfaces;
- and
- (b) a platelet-rich plasma gel composition capable of being injected through the membrane using a syringe within said void space created by the membrane and into contact with the inner surface of the membrane,
- wherein said platelet-rich plasma gel composition further comprises autologous cells of one type or a mixture of at least two types, and
- wherein when injected, the platelet-rich plasma gel composition is in contact with the inner surface of the flexible membrane,
- wherein said platelet-rich plasma gel composition further comprises a nanoparticulate mineral selected from the group consisting of hydroxyapatite, coralline hydroxyapatite, hydroxyapatite carbonate, bioactive glasses and ceramic, calcium phosphate ceramic, calcined bone, tricalcium phosphate,
- wherein the nanoparticulate mineral has an average particle diameter of 1 nm to 5 μm, and
- wherein the nanoparticulate mineral constitutes 0.01% to 60% by volume of the platelet-rich plasma gel composition.
5 more elements
A biocompatible implant for repair of a bone defect comprising in combination:
- (a) a flexible membrane comprising a biocompatible material having an inner and an outer surface shaped and sized for fitting around said bone defect to create an enclosed void space, said membrane being seeded with autologous cells on one or both surfaces;
- and
- (b) a platelet-rich plasma gel composition injectable via a syringe through the membrane, into said void space created by the membrane and into contact with the inner surface of the membrane,
- wherein said platelet-rich plasma gel composition further comprises autologous cells of one type or a mixture of at least two types,
- wherein when injected, the platelet-rich plasma gel composition is in contact with the inner surface of the flexible membrane,
- wherein said platelet-rich plasma gel composition further comprises a nanoparticulate mineral selected from the group consisting of hydroxyapatite, coralline hydroxyapatite, hydroxyapatite carbonate, bioactive glasses and ceramic, calcium phosphate ceramic, calcined bone, tricalcium phosphate,
- wherein the nanoparticulate mineral has an average particle diameter of 1 nm to 5 μm, and
- wherein the nanoparticulate mineral constitutes 0.01% to 60% by volume of the platelet-rich plasma gel composition.
5 more elements
Dependencies are inferred from the claim text.