Genetically engineered cyanobacteria
AssigneeSouth Dakota State University
InventorsRuanbao Zhou, William Gibbons
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Abstract
The disclosed embodiments provide cyanobacteria spp. that have been genetically engineered to have increased production of carbon-based products of interest. These genetically engineered hosts efficiently convert carbon dioxide and light into carbon-based products of interest such as long chained hydrocarbons. Several constructs containing polynucleotides encoding enzymes active in the metabolic pathways of cyanobacteria are disclosed. In many instances, the cyanobacteria strains have been further genetically modified to optimize production of the carbon-based products of interest. The optimization includes both up-regulation and down-regulation of particular genes.
Claims10
A composition comprising an Anabaena spp. genetically engineered with at least one recombinant polynucleotide expression construct, wherein the at least one recombinant polynucleotide expression construct comprises a nucleotide sequence encoding at least one enzyme, wherein the at least one enzyme increases production of a carbon based product of interest by the genetically engineered Anabaena spp. following expression of the polynucleotide expression construct, wherein said Anabaena spp. is ethanol producing Anabaena sp. PCC7120 (pZR672) strain deposited under ATCC accession number PTA-12833 or is linalool producing Anabaena sp. PCC7120 (pZR808) strain deposited under ATCC accession number PTA-12832.
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