Genes from 20q13 amplicon and their uses
AssigneesThe Regents of the University of California, The Hospital for Sick Children
InventorsJoe W. Gray, Colin Conrad Collins, Soo-In Hwang, Tony Godfrey, David Kowbel, Johanna Rommens
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Abstract
The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.
Claims9
A method of assaying for a prognostic indicator of breast cancer, the method comprising determining overexpression of the ZABC1 gene in a biological sample suspected of containing cancer cells, wherein overexpression of the ZABC1 gene, relative to normal tissue, indicates a poor prognosis, and wherein the method comprises determining ZABC1 protein level using an immunoassay that utilizes an antibody that specifically binds ZABC1.
Dependencies are inferred from the claim text.