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US 8,992,979 B2Granted
Sustained-release drug carrier composition
AssigneePolypid Ltd.
InventorsNoam Emanuel, Moshe Neuman, Shlomo Barak
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Abstract
The present invention provides compositions for extended release of one or more active ingredients, comprising a lipid-saturated matrix formed from a non-biodegradable polymer or a block-co-polymers comprising a non-biodegradable polymer and a biodegradable polymer. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of an active ingredient in the body of a subject in need thereof.
Claims28
A medical device comprising:
- a substrate and a biocompatible coating deposited on at least a fraction of said substrate, wherein the biocompatible coating comprises a non-liposomal matrix composition, the matrix composition comprising:
- (a) a biocompatible non-biodegradable polymer non-covalently associated with a first lipid comprising at least one sterol having a polar group;
- (b) a second lipid comprising at least one phospholipid having hydrocarbon chains of at least 14 carbons, wherein the biocompatible non-biodegradable polymer is not bonded to the second lipid;
- and
- (c) at least one pharmaceutically active agent;
- wherein the matrix composition is lipid saturated and when maintained in an aqueous environment provides zero-order release of least 40% the pharmaceutically active agent.
3 more elements
Dependencies are inferred from the claim text.