Anti-polyubiquitin antibodies and methods of use

An isolated monoclonal antibody that binds K11-linked polyubiquitin, wherein the antibody comprises an HVR-L1 sequence selected from SEQ ID NOs:

• 2 and 57 to 60, an HVR-L2 sequence selected from SEQ ID NOs:
• 3 and 61, an HVR-L3 sequence of SEQ ID NO:
• 4, an HVR-H1 sequence selected from SEQ ID NOs:
• 6 to 11, an HVR-H2 sequence selected from SEQ ID NOs:
• 12 to 17 and 67, and an HVR-H3 sequence selected from SEQ ID NOs:
• 18 to 23, 68 and 69.