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US 8,987,321 B2Granted
Lisofylline analogs and methods for use
AssigneeUniversity of Virginia Patent Foundation
InventorsTimothy L. MacDonald, Jerry L. Nadler, Peng Cui
Life of this patent
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Abstract
The present invention provides analogs of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF.
Claims12
A compound having formula II:
- wherein R1 is hydrogen or a group having the formula —C(═O)R3, wherein R3 is hydrogen or lower alkyl, and R2 is
- and n is 1 or 2;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.