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US 8,986,775 B2Granted
System and method for loading a beneficial agent into a medical device
AssigneeInnovational Holdings, LLC
InventorsJohn F. Shanley, Stephen Hunter Diaz, Theodore L. Parker
Life of this patent
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Abstract
A system for delivery of a beneficial agent in the form of a viscous liquid or paste allows holes in a medical device to be loaded in a single step process. The loading of a beneficial agent in a paste form also provides the ability to deliver large and potentially sensitive molecules including proteins, enzymes, antibodies, antisense, ribozymes, gene/vector constructs, and cells including endothelial cells.
Claims14
A method for loading a medical device with a beneficial agent, the method comprising:
- providing a medical device having tubular-shaped body with an exterior surface, an interior surface and a first interior space defined by the interior surface, and a first plurality of holes being defined on the exterior surface and intersecting the exterior surface;
- mounting the medical device on a tubular-shaped fixture such that the tubular-shaped fixture extends into the first interior space of the medical device, the tubular-shaped fixture having an outer surface, an inner surface, a thickness defined between the outer and inner surfaces, and a second interior space defined by the inner surface of the tubular-shaped fixture, a second plurality of through-holes being defined in the thickness of the tubular-shaped fixture;
- aligning the second plurality of holes with the first plurality of holes;
- delivering a beneficial agent into the second interior space;
- allowing the beneficial agent to fill the first plurality of holes in a paste form through the second plurality of holes, wherein the paste has a viscosity of at least 300 centipoise at 70° F.;
- and
- forming a drug delivery device with substantially no beneficial agent on the exterior surface of the medical device.
4 more elements
Dependencies are inferred from the claim text.