Treatment of urinary incontinence using nitrone spin traps
OwnerNicholas V. Perriconeinventor
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Abstract
Urinary incontinence is treated by administration of pharmaceutical compositions containing at least one nitrone spin trap such as α-phenyl t-butyl nitrone (PBN) and derivatives thereof. Preferred compositions and methods of treatment further comprise at least one adjunctive ingredient including fatty acid esters of ascorbic acid such as ascorbyl palmitate and ascorbyl stearate, and polyenylphosphatidylcholine.
Claims26
A method for the treatment of urinary incontinence, comprising administrating to a patient in need a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one nitrone spin trap having the formula (1):
- wherein
- X is phenyl or substituted phenyl with up to five substitution groups on the phenyl ring, wherein each said substitution groups is independently selected from the group consisting of hydrogen, halogen, alkaryl, alkoxyl, and alkenyl, and
- Y is selected from the group consisting of alkyl, substituted alkyl, alkenyl, alkynyl, naphthyl, heterocyclic, alkcycloalkyl, and cycloalkenyl.
Dependencies are inferred from the claim text.