Silicone-peroxide compositions for long-term, controlled oxygen release
AssigneesUniversity of Miami, Wake Forest University Health Sciences
InventorsCherie L. Stabler, Benjamin S. Harrison, Christopher A. Fraker, Eileen Pedraza, Camillo Ricordi
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Abstract
A composite for delivering extended-release of oxygen is disclosed. The composite can include a biocompatible polymeric support having a plurality of solid peroxide particles suspended therein. The polymer support can exhibit an oxygen tension value of at least 40 mmHg for a period of 14 days. The weight ratio of biocompatible polymeric support to solid peroxide particles can range from 1:1 to 99:1. Also disclosed is a method of using the composite to deliver oxygen to cells in both in vivo and in vitro environments.
Claims19
A composite for delivering extended-release of oxygen, comprising:
- a biocompatible polymeric support having a plurality of solid peroxide particles suspended therein, wherein said composite exhibits an oxygen tension value of at least 40 mmHg for a period of at least 14 days.
Dependencies are inferred from the claim text.