Medical device capable of being compacted and expanded having anti-thrombin III binding activity

A medical device comprising:

• a medical device that is capable of being compacted and expanded;
• a fluoropolymeric substrate material;
• a plurality of layers of a polymeric covering material attached to at least a portion of a surface of said substrate material and cross-linked, a biologically active substance having anti-thrombin III binding activity of at least 5 picomoles per square centimeter (pmol/cm2) of substrate material covalently attached to at least a portion of said layers of said polymeric covering material;
• and
• a biologically compatible glycosaminoglycan non-covalently combined with said polymeric covering material and said biologically active substance,
• wherein said biologically active substance has an anti-thrombin III binding activity of at least 5 picomoles anti-thrombin III per square centimeter (pmol/cm2) substrate material when measured following compaction of said medical device to 50% of said medical device's original size and expansion of said medical device.