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US 8,986,712 B2Granted
Peptides derived from HIV-1 gp41 transmembrane domain for t-immunomodulation
AssigneeYeda Research and Development Co. Ltd.
InventorsYechiel Shai, Irun R. Cohen, Tomer Cohen
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Abstract
The present invention relates to peptides, derivatives and analogs comprising an amino acid sequence derived from the transmembrane domain of HIV gp41 protein, pharmaceutical compositions comprising same, and uses thereof for therapy of inflammatory diseases and disorders, such as T-cell and/or monocyte mediated diseases.
Claims13
An isolated peptide of 10-30 amino acids, or an analog thereof, comprising the amino acid sequence of general formula I:
- (SEQ ID NO:
- 1)
- Gly-X1-X2-X3-Leu-X4-Ile-Val-Phe,
- wherein X1 is selected from the group consisting of a Leucine (Leu) and a Glycine (Gly) amino acid residue;
- X2 is selected from the group consisting of a Valine (Val) and a Leucine (Leu) amino acid residue;
- X3 is selected from the group consisting of a Glycine (Gly) and a Valine (Val) amino acid residue;
- and
- X4 is selected from the group consisting of an Arginine (Arg) and a Glutamic acid (Glu) amino acid residue;
- further comprising 1-4 basic amino acid residues contiguous to at least one termini of the amino acid sequence,
- wherein the analog comprises one or more D-amino acids.
7 more elements
Dependencies are inferred from the claim text.