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US 8,986,710 B2Granted
Neisseria meningitidis compositions and methods thereof
AssigneePfizer Inc.
InventorsAnnaliesa Sybil Anderson, Susan Kay Hoiseth, Kathrin Ute Jansen, Justin Keith Moran, Mark E. Ruppen
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Abstract
In one aspect, the invention relates to an isolated polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 71. In another aspect, the invention relates to an immunogenic composition including an isolated non-lipidated, non-pyruvylated ORF2086 polypeptide from Neisseria meningitidis serogroup B, and at least one conjugated capsular saccharide from a meningococcal serogroup.
Claims8
An isolated non-lipidated and non-pyruvylated polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO:
- 71, wherein an N-terminal cysteine at position 1 is deleted, as compared to SEQ ID NO:
- 70.
Dependencies are inferred from the claim text.