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US 8,986,705 B2Granted
Methods of producing influenza vaccine compositions
AssigneeMedImmune, LLC
InventorsGeorge Robert Trager, Vu Truong-Le, Luisa Yee
Life of this patent
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Abstract
Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
Claims13
A liquid refrigerator-stable live influenza virus composition, comprising:
- (a) one or more purified live influenza viruses;
- (b) less than 5% (v/v) normal allantoic fluid;
- and
- (c) a stabilizer consisting of:
- (i) sucrose, potassium phosphate and glutamate (SPG),
- (ii) 1% (w/v) to 5% (w/v) arginine, and
- (iii) 1% (w/v) to 4% (w/v) gelatin,
- wherein the composition when stored from 2° C. to 8° C. exhibits less than or equal to a 1.0 log potency loss in 6 months or less than or equal to a 0.080 log potency loss per month.
5 more elements
Dependencies are inferred from the claim text.