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US 8,986,696 B2Granted
Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
AssigneeDePuy Mitek, LLC
InventorsLaura J. Brown, Jeffery C. Geesin, Carrie H. Fang, John J. Siekierka
Life of this patent
Estimating the term…
Abstract
The present invention relates to trans-capsularly administering into a diseased joint an inhibitor of p38 MAP kinase or a different therapeutic agent.
Claims12
A method of treating an inflamed orthopedic joint in a human or an animal, said joint comprising:
- i) opposing hyaline cartilage articular surfaces;
- ii) peripheral to the surfaces, a central joint space comprising a collagenous capsule;
- and iii) synovial fluid contained within the joint space, the method comprising directly administering into the joint space by trans-capsular administration a formulation comprising an effective amount of a compound of one of the following structural formulas:
- or a salt thereof.
1 more element
A method of treating a degenerative joint disease in an inflamed orthopedic joint in a human or an animal, said joint comprising:
- i) opposing hyaline cartilage articular surfaces;
- ii) peripheral to the surfaces, a central joint space comprising a collagenous capsule;
- and iii) synovial fluid contained within the joint space, the method comprising directly administering into the joint space by trans-capsular administration a formulation comprising an effective amount of a compound of one of the following structural formulas:
- or a salt thereof.
1 more element
Dependencies are inferred from the claim text.