Targeting human nav1.7 variants for treatment of pain
AssigneeKymab Limited
InventorJasper Rupert Clube
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Abstract
The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
Claims28
A method of treating pain in a human in need thereof, the method comprising administering to said human an antibody or antibody fragment that specifically binds a human Nav1.7 protein that comprises a mutation selected from the group consisting of:
- 1161W, 1919G, 490N, 1002L, 422D and 943L in SEQ ID NO:
- 75;
- wherein the antibody or antibody fragment comprises a human gamma-2 heavy chain constant region that comprises an amino acid selected from the group consisting of:
- a Pro at position 72 shown in SEQ ID NO:
- 6;
- an Asn at position 75 shown in SEQ ID NO:
- 6;
- a Phe at position 76 shown in SEQ ID NO:
- 6;
- a Val at position 161 shown in SEQ ID NO:
- 6 and an Ala at position 257 shown in SEQ ID NO:
- 6;
- and
- wherein said human comprises
- (i) an IGHG2*01 human heavy chain constant region gene segment, or the human expresses antibodies comprising human gamma-2 heavy chain constant regions comprising said selected amino acid;
- and wherein
- (ii) said human comprises a nucleotide sequence encoding said Nav1.7 protein comprising said selected mutation in SEQ ID NO:
- 75.
A method of treating or reducing the risk of pain in a human in need thereof, the method comprising administering to said human an antibody or antibody fragment that specifically binds a human Nav1.7 protein encoded by a nucleotide sequence that comprises a SNP selected from the group consisting of:
- rs6746030, rs3750904, rs58022607, rs4369876, rs13402180 and rs12478318;
- wherein (i) the antibody or fragment comprises a human gamma-2 heavy chain constant region that comprises an amino acid selected from the group consisting of:
- a Pro at position 72 shown in SEQ ID NO:
- 6;
- an Asn at position 75 shown in SEQ ID NO:
- 6;
- a Phe at position 76 shown in SEQ ID NO:
- 6;
- a Val at position 161 shown in SEQ ID NO:
- 6 and an Ala at position 257 shown in SEQ ID NO:
- 6;
- and
- and (ii) said human comprises an IGHG2*01 human heavy chain constant region gene segment, or the human expresses antibodies comprising human gamma-2 heavy chain constant regions comprising said amino acid selected from the group consisting of:
- a Pro at position 72 shown in SEQ ID NO:
- 6;
- an Asn at position 75 shown in SEQ ID NO:
- 6;
- a Phe at position 76 shown in SEQ ID NO:
- 6;
- a Val at position 161 shown in SEQ ID NO:
- 6 and an Ala at position 257 shown in SEQ ID NO:
- 6;
- and
- wherein (iii) said human comprises a nucleotide sequence encoding a human Nav1.7 protein comprising said SNP selected from the group consisting of rs6746030, rs3750904, rs58022607, rs4369876, rs13402180 and rs12478318.
Dependencies are inferred from the claim text.