Method of treating atopic dermatitis or asthma using antibody to IL4RA

A method of treating or reducing the risk of atopic dermatitis or asthma in a human in need thereof, the method comprising administering to said human an antibody or antibody fragment that specifically binds a human IL4Ra protein that comprises a mutation selected from the group consisting of:

• I75V, E400A, C431R, S503P, Q576R and S752A in SEQ ID NO:
• 67;
• wherein the antibody or antibody fragment comprises a human gamma-4 heavy chain constant region that comprises an amino acid selected from the group consisting of:
• a Leu at position 189 shown in SEQ ID NO:
• 73 and an Arg at position 289 shown in SEQ ID NO:
• 73 and
• wherein said human comprises
• (i) an IGHG4*01 human heavy chain constant region gene segment, or the human expresses antibodies comprising human gamma-4 heavy chain constant regions comprising said selected amino acid;
• and wherein
• (ii) said human comprises a nucleotide sequence encoding said IL4Ra protein comprising said selected mutation.