Compositions and methods for brain delivery of analgesic peptides
AssigneeNational Research Council of Canada
InventorsDanica Stanimirovic, Abedelnasser Abulrob, Eric Brunette, Nadia Caram-Salas
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Abstract
The present invention relates to non-invasive brain delivery technology for centrally-acting analgesic peptides. Specifically, the invention is directed to compounds comprising an antibody or fragment thereof capable of transmigrating across the blood brain barrier (BBB) and an analgesic peptide. Compositions and methods of using the compounds or compositions are also provided.
Claims7
A compound comprising a single domain antibody (sdAb) capable of transmigrating across the blood brain barrier (BBB) and an analgesic peptide, wherein the antibody or fragment thereof comprises:
- complementarity determining region (CDR) 1 sequence HYTMG (SEQ ID NO:1);
- CDR2 sequence RITWGGDNTFYSNSVKG (SEQ ID NO:2);
- and
- CDR3 sequence GSTSTATPLRVDY (SEQ ID NO:3);
- wherein the analgesic peptide acts on opioid receptors, neuropeptide Y receptors, neurotensin receptors, galanin receptors, orexin receptors, somatostatin receptors, or any combination thereof.
Dependencies are inferred from the claim text.