Methods and compositions concerning poxviruses and cancer
AssigneeSillajen Biotherapeutics, Inc.
InventorsDavid Kirn, Steve H. Thorne
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Abstract
The present invention concerns methods and compositions for the treatment of cancer and cancer cells using altered poxviruses, including a vaccinia virus that has been altered to generate a more effective therapeutic agent. Such poxviruses are engineered to be attenuated or weakened in their ability to affect normal cells. In some embodiments, methods and compositions involve poxviruses that possess mutations that result in poxviruses with diminished or eliminated capability to implement an antiviral response in a host. Poxviruses with these mutations in combination with other mutations can be employed for more effective treatment of cancer.
Claims14
A method for treating cancer in a subject comprising administering to the subject an attenuated Western Reserve strain vaccinia virus comprising a mutation in a gene encoding an interferon modulating polypeptide selected from B8R and B18R that results in the virus having a reduced ability to inhibit an antiviral response mediated by an interferon.
A method for treating cancer in a subject comprising administering to the subject an attenuated vaccinia virus comprising a mutation in a gene encoding B8R and a mutation in a gene encoding B18R said mutations resulting in the virus having a reduced ability to inhibit an antiviral response mediated by an interferon.
Dependencies are inferred from the claim text.