Compositions, devices, and methods related to prostate-specific membrane antigen
AssigneeThe Regents of the University of California
InventorsGregory A. Weiss, Jessica Arter, Juan E. Diaz
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Abstract
PSMA ligands, compositions, and methods therefore are disclosed where the ligand is a peptide having the sequence X1X2CVEVX3QNSCX4X5 where X1-X5 are independently a natural or non-natural amino acid or a peptide having the sequence CALCEFLG [SEQ ID NO: 1]. Especially preferred aspects include diagnostic reagents for detection and/or quantification of PSMA in a sample, therapeutic reagents, and diagnostic imaging reagents.
Claims18
A recombinantly produced or synthetically produced PSMA binding reagent comprising a PSMA binding peptide having the sequence X1X2CVEVX3QNSCX4X5 [SEQ ID NO:
- 2], wherein X1 to X5 are independently a natural amino acid or a non-natural amino acid, or having the sequence CALCEFLG [SEQ ID NO:
- 1] covalently linked either directly or indirectly to one or more moieties selected from the group consisting of an imaging contrast agent, an enzyme, a toxin, a detectable label, a protecting group, a therapeutic moiety, and a solid phase.
Dependencies are inferred from the claim text.