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US 8,986,378 B2Granted
Implantable collagen devices and related methods and systems of making same
AssigneeMiMedx Group, Inc.
InventorThomas J. Koob
Life of this patent
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Abstract
The invention relates to implantable collagen devices made by seeding at least one elongate collagen construct, e.g., comprising at least one elongate synthetic collagen fiber with a plurality of cells and applying a strain and/or stress to the at least one elongate collagen fiber to induce the cells to differentiate into target phenotypes, e.g., tendon or ligament phenotype cells (and/or fibroblasts), typically with an extracellular matrix of collagen to organize into a tissue on the at least one collagen fiber.
Claims22
An implantable collagen fiber construct, comprising:
- a plurality of elongate collagen fibers;
- and
- a plurality of cells attached to the elongate collagen fibers,
- wherein ex vivo the cells comprise tendon or ligament phenotype cells and an extracellular matrix comprising collagen, wherein collagen is present in an amount greater than other extracellular matrix proteins.
1 more element
A medical material, comprising:
- at least one elongate synthetic collagen fiber;
- and
- a plurality of cells attached to the at least one elongate synthetic collagen fiber,
- wherein ex vivo the cells comprise defined phenotype cells and an extracellular matrix comprising collagen, wherein collagen is present in an amount greater than other extracellular matrix proteins.
1 more element
Dependencies are inferred from the claim text.