Injection of fibrin sealant using reconstituted components in spinal applications

A method of treating a human back, comprising injecting a fibrin sealant into the nucleus pulposus of a disc, wherein neither a nucleus pulposus nor an annulus fibrosus has been previously heated, to seal at least one defect of the annulus fibrosus, wherein the fibrin sealant comprises fibrinogen and thrombin, wherein the fibrinogen and thrombin forms at least a portion of the fibrin after injection, wherein the fibrinogen, the thrombin or both has been reconstituted with a solution containing at least one additive, wherein the fibrin sealant does not include a corticosteroid, and wherein normal hydrostatic pressure in the disc is restored or normal disc height is restored or both.

A method of treating a human back, comprising providing a mixture of fibrinogen and thrombin within a human disc to treat at least one defect of an annulus fibrosus wherein neither a nucleus pulposus nor the annulus fibrosus has been heated, and wherein the fibrinogen, the thrombin or both has been reconstituted with a solution containing at least one additive, and wherein a corticosteroid is absent from the mixture, and wherein the injecting occurs by inserting an introducer needle having a tip into an intra-discal space, inserting a second needle or a polymeric catheter through the introducer needle up to but not beyond the tip of the introducer needle, and injecting the fibrinogen through the introducer needle and injecting the thrombin through the second needle or polymeric catheter, or injecting the thrombin through the introducer needle and injecting the fibrinogen through the second needle or polymeric catheter.