Apparatus and methods for clot dissolution

A method for disrupting clot over a luminal length of a blood vessel, said method comprising:

• positioning a catheter at a location within the luminal length of the blood vessel at a desired treatment region, the catheter comprising,
• a catheter body comprising a proximal end and a distal end and having at least one lumen therethrough;
• an inner catheter shaft comprising a proximal end and a distal portion having at least one lumen allowing passage of a wire or agitator, the distal portion of the inner catheter shaft having at least one port formed therein so as to permit fluid flow from the lumen inner catheter shaft, the inner catheter shaft being configured to slidably couple within the at least one lumen in the catheter body;
• a proximal isolation balloon disposed adjacent the distal end of the catheter body;
• a distal isolation balloon disposed adjacent a distal end of the inner catheter shaft;
• and
• an agitator that is rotatable and/or axially translatable for mechanical disruption of a clot in a blood vessel, the agitator comprising a non-linear region disposed in the inner catheter shaft lumen such that the at least one port is positioned along a distal portion of the non-linear region and the inner catheter shaft assumes the non-linear shape of the non-linear region of the agitator along a length of the non-linear region;
• inflating the proximal isolation balloon at a proximal end of the desired treatment region;
• extending the distal isolation balloon a desired distance from the proximal isolation balloon and then inflating the distal isolation balloon to define an isolated treatment region;
• infusing a thrombolytic agent into the isolated treatment region through the at least one port formed in the inner catheter shaft;
• and
• actuating the agitator for mechanical disruption of a clot.