Unit dose breakable vial with integrated brush applicator

A method of applying a therapeutic topical agent to a body part, wherein the method comprises:

• applying a force to a handle section and a vial section of a breakable vial, wherein:
• the breakable vial is completely separable into the handle section and the vial section in response to a manually applied separation force;
• the vial section comprises a sterile void containing a unit dose of a therapeutic topical agent, wherein the therapeutic topical agent comprises a prostaglandin analog;
• the handle section comprises a sterile applicator comprising a handle, a shaft, and a brush, the handle section supporting the handle, and at least a portion of the shaft and the brush being completely enclosed within the breakable vial with the brush extending into the sterile void and immersed in the therapeutic topical agent, wherein the brush has a generally tapered shape comprising bristles of differing length that serves to trap the therapeutic topical agent using capillary action and comprises multiple bristles molded thereto;
• and
• a hermetic seal between the vial section and the handle section that maintains sterility of the void, the therapeutic topical agent, the shaft, and the brush prior to separation of the handle section and vial section, wherein complete separation of the handle section and the vial section exposes the sterile shaft and the brush for topical application of the therapeutic agent saturating the brush;
• separating the handle section from the vial section;
• and,
• applying the therapeutic topical agent to the body part.