Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same
AssigneeThe University of North Carolina at Chapel Hill
InventorsMark Schoenfisch, Daniel Riccio
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Abstract
Provided according to embodiments of the invention are novel tertiary alkyl thiol compounds and novel tertiary alkyl nitrosothiol compounds. Further provided according to embodiments of the invention are methods of forming a nitric oxide (NO)-releasing xerogel coating that include (a) co-condensing a sol precursor solution comprising at least one backbone alkoxysilane and at least one tertiary thiol alkoxysilane in a solvent to form a sol; (b) coating a substrate with the sol; (c) optionally, drying the sol to form the xerogel coating; and (d) contacting the xerogel coating with a nitrosating agent. Methods of using xerogel coatings are also included.
Claims20
A co-condensed silica sol-gel coating formed from the reaction of the compound of Formula I and at least one backbone alkoxysilane:
- wherein R, R′ and R″ are each independently alkyl and n is in a range of 0 to 10.
A sol-gel coating comprising a tertiary S-nitrosothiol.
A method of forming a nitric oxide (NO)-releasing sol-gel coating comprising:
- (a) co-condensing a sol precursor solution comprising at least one backbone alkoxysilane and at least one tertiary thiol alkoxysilane in a solvent to form a sol;
- (b) coating a substrate with the sol;
- (c) optionally, drying the sol to form the sol-gel coating;
- and
- (d) contacting the sol-gel coating with a nitrosating agent.
Dependencies are inferred from the claim text.