B7-H1 Antibodies
AssigneeMayo Foundation for Medical Education and Research
InventorLieping Chen
Life of this patent
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Abstract
The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides.
Claims27
An isolated antibody that binds specifically to a B7-H1 polypeptide which comprises
- (a) amino acids having the sequence set forth in SEQ ID NO:1;
- or
- (b) amino acids that are encoded by a polynucleotide comprising nucleotides having the sequence set forth in SEQ ID NO:2.
An antibody fragment that specifically binds to a B7-H1 polypeptide which comprises
- (a) amino acids having the sequence set forth in SEQ ID NO:1;
- or
- (b) amino acids that are encoded by a polynucleotide comprising nucleotides having the sequence set forth in SEQ ID NO:2.
An isolated antibody which selectively binds to a B7-H1 polypeptide which
- (a) comprises amino acids having a sequence from amino acid residue 23 to amino acid residue 239 of SEQ ID NO:1.
An isolated antibody or an antigen binding fragment thereof which selectively binds to the polypeptide of SEQ ID NO:1.
An isolated antibody or an antigen binding fragment thereof which specifically binds to a polypeptide consisting of amino acids having the sequence set forth in SEQ ID NO:1.
A method of making an antibody, or an antigen binding fragment thereof comprising:
- providing a polypeptide which is (a) a polypeptide comprising amino acids having the sequence set forth in SEQ ID NO:1;
- or (b) a polypeptide which is encoded by a polynucleotide comprising nucleotides having the sequence set forth in SEQ ID NO:2 to an immunocompetent vertebrate;
- and
- harvesting from the vertebrate blood or serum comprising an antibody which specifically binds to said polypeptide, or an antigen binding fragment thereof.
An antibody or an antigen binding fragment thereof which binds to a soluble B7-H1 polypeptide which is not membrane-bound, wherein said soluble B7-H1 polypeptide comprises amino acid domain(s) having the sequence(s) shown in FIG. 2A (SEQ ID NO:1) such that the polypeptide is soluble.
Dependencies are inferred from the claim text.