Back to results
US 8,980,864 B2Granted
Compositions and methods of altering cholesterol levels
AssigneeModerna Therapeutics, Inc.
InventorsStephen G. Hoge, Antonin de Fougerolles, Jeff Lynn Ellsworth
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.
Claims5
A method of reducing serum levels of cholesterol in a subject comprising administering to said subject a modified mRNA encoding a LDLR mutant, said modified mRNA comprising at least one nucleoside modification, wherein said at least one nucleoside modification is 1-methylpseudouridine and wherein said modified mRNA encodes a protein identical to SEQ ID NO:
- 19 except for one or more substitution mutations that change the identity of one or more amino acids at one or more of positions 316-339 of SEQ ID NO:
- 19 in combination with an mRNA encoding a CYP7A1 protein, said mRNA comprising the base sequence of SEQ ID NO:
- 39 except that each thymidine is replaced by a uridine.
Dependencies are inferred from the claim text.