Arginine inactivation of viruses
AssigneeBiogen Idec MA Inc.
InventorsKeith Selvitelli, Justin McCue
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Abstract
The present invention pertains to methods of using arginine to inactivate or reduce the infectious titer of enveloped viruses potentially present in biological compositions produced by eukaryotic cells (such as a antibodies or other therapeutic proteins). In some embodiments, inactivation or reduction of viral titers by exposure to arginine is achieved in a neutral (pH ˜7) or near neutral (˜pH 6 to ˜pH 8) environment.
Claims35
A method of inactivating or reducing the infectious titer of a retrovirus comprising contacting said virus with arginine, wherein said contacting occurs in a solution comprising at least about 0.2 M arginine and wherein said solution is at a pH above about 6.0.
Dependencies are inferred from the claim text.