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US 8,980,326 B2Granted
Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents
AssigneeIntezyne Technologies, Inc.
InventorsKevin N. Sill, Habib Skaff, Kurt Breitenkamp
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Abstract
The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
Claims5
A multiblock copolymer of formula I:
- wherein:
- n is 275±10;
- m is 5-25;
- m′ is 5-50;
- Rx is a glutamic acid side-chain or an aspartic acid side-chain;
- Ry consists of a mixture of D- and L-amino acid side-chain groups selected from:
- D-benzylglutamate and L-benzylglutamate,
- D-benzylaspartate and L-benzylaspartate,
- D-leucine and L-tyrosine, or
- D-phenylalanine and L-tyrosine,
- wherein the Ry block is not in the form of an α-helix;
- R1 is —N3 or —OCH3;
- Q is a valence bond;
- and
- R2a is —NHC(O)CH3.
12 more elements
A multiblock copolymer of the following structure:
- wherein w is 50 to 400, x is 5-25, y is 1-50, z is 1-50, and p is 5-50, wherein p is the sum of y and z wherein the leucine/tyrosine block is not an α-helix.
Dependencies are inferred from the claim text.