Back to results
US 8,978,161 B2Granted
Targeted sequencing of biomolecules by pulling through a liquid-liquid interface with an atomic force microscope
AssigneeInternational Business Machines Corporation
InventorsVenkat K. Balagurusamy, Stanislav Polonsky
Life of this patent
Estimating the term…
Abstract
A mechanism is provided for sequencing a biopolymer. The biopolymer is traversed from a first medium to a second medium. The biopolymer includes bases. As the biopolymer traverses from the first medium to the second medium, different forces are measured corresponding to each of the bases. The bases are distinguished from one another according to the different measured forces which are measured for each of the bases.
Claims11
A method of sequencing a block copolymer, comprising:
- traversing the block copolymer from a first medium to a second medium;
- wherein the block copolymer comprises first blocks and second blocks;
- measuring a first measured force when the first blocks traverse from the first medium to the second medium;
- measuring a second measured force when the second blocks traverse from the first medium to the second medium, the first measured force being different from the second measured force;
- identifying the first blocks of the block copolymer based on measuring the first measured force;
- and
- identifying the second blocks of the block copolymer based on measuring the second measured force.
4 more elements
Dependencies are inferred from the claim text.