Fluorescent nanoparticles
AssigneeSignalomics GmbH
InventorsSven Laarmann, Kathrin Zeller, Karin Mittmann, Christoph Block, Claudia Arntz
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Abstract
The use of fluorescent nanoparticles is disclosed which includes an inorganic core, a passivating layer and specific ligands having a hydrodynamic diameter of the inorganic core with the passivating layer of not more than 15 nm, preferably of not more than 10 nm, particularly preferably of not more than 5 nm, for preparing an in vivo diagnostic aid, the nanoparticles showing an emission of less than 700 nm.
Claims18
A method of using fluorescent nanoparticles for in vivo tissue marking in surgical, endoscopic or minimally invasive interventions, the method comprising administering to or injecting into a human in need thereof, for in vivo tissue marking in surgical, endoscopic or minimally invasive interventions, the fluorescent nanoparticles, wherein the fluorescent nanoparticles comprise an inorganic core, a passivating layer comprising an imidazole component, and specific ligands, and having a hydrodynamic diameter of the inorganic core with the passivating layer of not more than 15 nm, wherein the nanoparticles show an emission of less than 700 nm.
A method of using fluorescent nanoparticles for in vivo tissue marking in surgical, endoscopic or minimally invasive interventions, the method comprising administering to or injecting into a human in need thereof, for in vivo tissue marking in surgical, endoscopic or minimally invasive interventions, the fluorescent nanoparticles, wherein the fluorescent nanoparticles comprise an inorganic core, a passivating layer comprising an imidazole component, and specific ligands, and having a hydrodynamic diameter of the inorganic core with the passivating layer of not more than 15 nm, said nanoparticles show an emission of less than 700 nm, and wherein marking permits differentiating abnormal, precarcinogenic or carcinogenic tissue from normal tissue.
Dependencies are inferred from the claim text.