Brush polymer and medical use thereof
AssigneeIndustrial Technology Research Institute
InventorsJui-Hsiang Chen, Jean-Dean Yang, Yu-Hua Chen, Ting-Yu Shih, Chia-wei Hong, Chao-Chen Tien
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Abstract
The present disclosure provides a brush polymer, including: a linear polymer main chain; and brush structural side chains, including: a hydrophobic molecular branch, and a hydrophilic molecular branch and/or an anti-biofilm/or an anti-microbial molecular branch, wherein the linear polymer main chain is conjugated to the side chains by covalent bonds formed between a hydroxyl group and a reactive functional group, wherein the reactive functional group includes: isocyanate, carboxyl, or epoxy. The present disclosure also provides a medical application of the brush polymer.
Claims17
A brush polymer, comprising:
- (a) a linear polymer main chain;
- and
- (b) brush structural side chains, comprising:
- (b1) a hydrophobic molecular branch, wherein the hydrophobic molecular branch comprises polyurethane, and
- (b2) a hydrophilic molecular branch and an anti-biofilm or an anti-microbial molecular branch, wherein the anti-biofilm or the anti-microbial molecular branch comprises farnesol, xylitol, lactoferrin, ethylene diamine tetraacetic acid (EDTA), gallium, PNAG-degrading enzyme, RNA-III inhibiting peptide, furanone C30, silver, iodine, zinc, copper, an antibiotic, medicine or combinations thereof,
- wherein the linear polymer main chain is conjugated to the brush structural side chains by covalent bonds formed between a hydroxyl group and a reactive functional group, wherein the reactive functional group comprises:
- isocyanate, carboxyl, or epoxy, wherein the anti-biofilm or the anti-microbial molecular branch conjugates onto the linear polymer main chain by a covalent bond.
The brush polymer of claim l, wherein the hydrophobic molecular branch comprises:
- aliphatic polyurethane, aromatic polyurethane, or combinations thereof.
Dependencies are inferred from the claim text.