Methods of treating autoimmune diseases with anti-FcεRI antibodies
AssigneeThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
InventorsEdward E. Mitre, Marc P. Hübner
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Abstract
Methods of using anti-FceRI or anti-IgE antibodies for treating an autoimmune disease are disclosed. Also disclosed is a composition comprising an anti-FceRI antibody or anti-IgE antibody for use in treating an autoimmune disease. Also disclosed are non-antibody compounds that specifically activate basophils and/or mast cells, either by cross-linking IgE or FceRI, or by activating the cells through an FceRI-independent pathway and methods of using the same to treat autoimmune diseases.
Claims12
A method of treating a Th1-mediated autoimmune disease in a subject, the method comprising administering to the subject an effective amount of an antibody, or antigen-binding fragment thereof, that binds to the Fc epsilon receptor I (FcεRI), thereby treating the Th1-mediated autoimmune disease, and wherein the antibody is administered in an amount sufficient to crosslink the FcεRI on basophils and/or mast cells, thereby activating the basophils and/or mast cells.
Dependencies are inferred from the claim text.