Apparatus and method for thermal assisted desorption ionization systems
AssigneeIonsense, Inc.
InventorsJordan Krechmer, Brian D. Musselman
Life of this patent
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Abstract
The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.
Claims20
A kit for analyzing an analyte comprising:
- one or more mesh, where the analyte is applied on or near at least one or the one or more mesh;
- a holder adapted to position the one or more mesh in a region between a source for generating ionizing species and an entrance of a spectrometer;
- and
- a heating supply adapted to heat the one or more mesh positioned in the holder while a plurality of ionizing species formed by the source are directed at the one or more mesh, where analyte molecules desorbed one or both from and near the one or more mesh interact with the ionizing species to form one or more analyte ions which pass through the entrance of the spectrometer and are analyzed.
A kit for analyzing an analyte comprising:
- one or more mesh, where at least one of the one or more mesh have been contacted with the analyte;
- a source for generating ionizing species;
- a spectrometer with an entrance;
- a holder adapted to position the one or more mesh between the source and the entrance of the spectrometer;
- and
- a heating supply adapted to heat the one or more mesh positioned in the holder while a plurality of ionizing species formed by the source are directed at the one or more mesh, where analyte molecules desorbed from the one or more mesh interact with the ionizing species to form one or more analyte ions which pass through the entrance of the spectrometer and are analyzed.
A kit for analyzing an analyte comprising:
- one or more mesh;
- a holder adapted to position the one or more mesh between a source for generating ionizing species and an entrance of a spectrometer;
- and
- a liquid introduction system for introducing an analyte solution containing the analyte near at least one or the one or more mesh positioned in the holder;
- a heating supply adapted to heat the one or more mesh positioned in the holder while the liquid introduction system introduces the analyte solution near the one or more mesh and a plurality of ionizing species formed by the source are directed at the one or more mesh, where gaseous analyte molecules formed near the one or more mesh interact with the ionizing species to form one or more analyte ions which pass through the entrance of the spectrometer and are analyzed.
Dependencies are inferred from the claim text.