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US 8,961,962 B2Granted
Acid ceramidase and mammalian cell survival
AssigneeMount Sinai School of Medicine
InventorsEdward H. Schuchman, Efrat Eliyahu, Nataly Shtraizent, Xingxuan He
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Abstract
The present invention relates to methods of promoting the survival of cells by treating the cells with acid ceramidase. A kit for promoting ex vivo cell survival is also disclosed, as is a method of predicting in vitro fertilization outcome of a female subject.
Claims7
A method of promoting the ex vivo survival of mammalian cells, said method comprising:
- providing one or more mammalian cells ex vivo, wherein the one or more mammalian cells are selected from the group consisting of eggs, primary cells, neurons, sperm, synovial fibroblasts, and embryonic stem cells;
- and
- treating the one or more mammalian cells with acid ceramidase under conditions effective to promote survival of the one or more mammalian cells.
Dependencies are inferred from the claim text.