Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
AssigneesaTyr Pharma, Inc., Pangu BioPharma Limited
InventorsKyle P. Chiang, Jeffry Dean Watkins, Alain Philippe Vasserot, Cheryl L. Quinn, John D. Mendlein, Wing-Sze Lo, Fei Hong, Leslie Ann Greene
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Abstract
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Claims15
A therapeutic composition, comprising an isolated isoleucyl-tRNA synthetase (IleRS) polypeptide of up to about 500 amino acids in length and comprising an amino acid sequence that is at least 95% identical to SEQ ID NO:32, wherein the polypeptide has an extracellular signaling activity and a solubility of at least about 5 mg/mL, and wherein the composition has a purity of at least about 95% on a protein basis and less than about 10 EU endotoxin/mg protein.
Dependencies are inferred from the claim text.