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US 8,957,041 B2Granted
Short interfering ribonucleic acid (siRNA) for oral administration
AssigneeNovartis AG
InventorsFrancois Jean-Charles Natt, Eric Billy, Juerg Hunziker, Christian Rene Schnell
Life of this patent
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Abstract
Short interfering ribonucleic acid (siRNA) for oral administration, said siRNA comprising two separate RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein at least one of which strands contains at least one chemical modification.
Claims21
A method for the inhibition of a target gene in a cell comprising the step of:
- introducing into the cell a short interfering ribonucleic acid (siRNA) which is capable of inhibiting the target gene by RNA interference,
- wherein said siRNA comprises two RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein the 3′-terminus of at least one strand comprises a modification at the 3′ carbon, wherein the modification is:
A method for the inhibition of a target gene in a cell comprising the step of:
- introducing into the cell a short interfering ribonucleic acid (siRNA) which is capable of inhibiting the target gene by RNA interference,
- wherein said siRNA comprises two RNA strands that are complementary to each other over at least 15 nucleotides, wherein each strand is 49 nucleotides or less, and wherein the 3′-terminus of each strand comprises a modification at the 3′ carbon, wherein the modification is:
Dependencies are inferred from the claim text.