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US 8,952,136 B2Granted
Antibodies to human programmed death receptor PD-1
AssigneeMerck Sharp & Dohme Corp.
InventorsGregory John Carven, Hans Van Eenenneem, Gradus Johannes Dulos
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Abstract
Antibodies which block binding of hPD-1 to hPD-L1 or hPD-L2 and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune cell through the PD-1 pathway is also disclosed.
Claims3
An isolated antibody or antibody fragment which binds to human programmed death receptor-1 (PD-1), comprising
- a. light chain CDRs of SEQ ID NOs:
- 9, 10 and 11;
- and
- b. heavy chain CDRs of SEQ ID NOs:
- 12, 13 and 14;
- wherein said antibody or antibody fragment blocks binding of human PD-L1 and human PD-L2 to human PD-1.
3 more elements
Dependencies are inferred from the claim text.