Methods and compositions for the treatment of insulin-associated medical conditions
AssigneeYeda Research and Development Co. Ltd.
InventorsEran Hornstein, Tal Melkman-Zehavi, Roni Oren
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Abstract
A method of increasing insulin content in a pancreatic beta cell is disclosed. The method comprising expressing in the pancreatic beta cell an exogenous polynucleotide encoding at least one microRNA or a precursor thereof, wherein the microRNA is selected from the group consisting of miR-15, miR-16, miR-24, miR-26, miR-27, miR-29, miR-30, miR-129, miR-141, miR-148, miR-182, miR-200, miR-376 and Let-7, thereby increasing the insulin content in the pancreatic beta cell.
Claims5
A method of increasing an insulin content in a pancreatic beta cell, the method comprising expressing in the pancreatic beta cell an exogenous polynucleotide encoding at least one microRNA or a precursor thereof, wherein said microRNA is selected from the group consisting of miR-15, miR-16, miR-24, miR-26, miR-27, miR-129, miR-148, miR-182 and miR-200, thereby increasing the insulin content in the pancreatic beta cell.
A method of increasing an insulin content in a pancreatic beta cell in a subject in need thereof, wherein said subject has an insulin deficiency, the method comprising administering to the subject an exogenous polynucleotide encoding at least one microRNA or a precursor thereof, wherein said microRNA is selected from the group consisting of miR-15, miR-16, miR-24, miR-26, miR-27, miR-129, miR-148, miR-182 and miR-200, thereby increasing the insulin content in the pancreatic beta cell in said subject.
Dependencies are inferred from the claim text.