Compositions for improving migration potential of stem cells
AssigneeCorestem Co., Ltd.
InventorsSeong Ho Koh, Seung Hyun Kim, Goang Won Cho, Min Young Noh, Kyung Suk Kim
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Abstract
The present invention relates to a composition for improving the migration potential of a stem cell, a method for evaluating the migration potential of a stem cell and a method for screening an adjuvant of cell therapy improving the migration potential of a stem cell. The present invention may be effectively used for enhancing the efficacy of neurological disease-treatment by inducing therapeutic stem cells to migrate efficiently to the lesion site.
Claims4
A method for improving the migration potential of a mesenchymal stem cell, comprising introducing into the mesenchymal stem cell a gene delivery system that expresses a nucleotide sequence encoding β-PIX having the amino acid sequence of SEQ ID NO:2 in the mesenchymal stem cell, wherein expression of said nucleotide sequence improves the migration potential of said mesenchymal stem cell when compared to a mesenchymal stem cell that does not express said nucleotide sequence.
Dependencies are inferred from the claim text.