US 8,948,863 B2 · Photokinetic ocular drug delivery methods and apparatus

Abstract

The present invention relates generally to transscleral, transcorneal, and transocular delivery of biologically active substances through the tissues, blood vessels and cellular membranes of the eyes of patients without causing damage to the cellular surface, tissue or membrane. The invention provides compositions and methods for enhanced transscleral, transcorneal and transocular delivery of biologically active substances using pulsed incoherent light, and particularly the transcleral, transcorneal or transocular delivery of high molecular weight biologically active substances to a patient using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes of the eye of a subject using those compositions and methods.

Claims22

Dependent claims

A device for photokinetic transscleral ocular drug delivery, the device comprising:

a generator that provides an oscillating electrical pulse in electrical communication with at least one light emitting diode (LED) that is mounted on a photokinetic patch adapted and dimensioned to be inserted under an eyelid and fit against an external ocular surface of an eye of a patient, the photokinetic patch including a drug layer, wherein the at least one LED receives the oscillating electrical pulse and responds by providing an incoherent light directed through the drug layer and towards an interior of the eye of the patient at a wavelength selected to induce a photokinetic transocular translocation of a drug loaded in the drug layer.

Dependencies are inferred from the claim text.

Facts

Application

12/903,126Filed 12 Oct 2010 · us provisional application

Priority

9 Oct 2009

Published

US 2011/0125076 A126 May 2011

Granted

3 Feb 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification27 codes

A61K 41/0057
Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations: photodynamic…
A61F 9/0017
Introducing ophthalmic products into the ocular cavity or retaining products therein: implantable in, or in contact with, the eye, e.g. ocular inserts
A61K 9/0048
Galenical forms characterised by the site of application: eye, e.g. artificial tears
A61K 31/167
Having aromatic rings, e.g. colchicine, atenolol, progabide: having the nitrogen of a carboxamide group directly attached to the aromatic ring,…

Photokinetic ocular drug delivery methods and apparatus

Life of this patent

Photokinetic ocular drug delivery methods and apparatus

Life of this patent

Abstract

Claims22