Back to results
US 8,948,852 B2Granted
Imaging volumes with arbitrary geometries in non-contact tomography
AssigneeVisEn Medical, Inc.
InventorsJorge Ripoll Lorenzo, Vasilis Ntziachristos, Karen Madden
Life of this patent
Estimating the term…
Abstract
A method for tomographic imaging of diffuse medium includes directing waves into a diffusive medium, solving a surface-bounded inversion problem by forward field calculations through decomposition of contributions from the multiple reflections from an arbitrary surface within the diffusive medium or outside the diffusive medium into a sum of different orders of reflection up to an arbitrary order, and using contact or non-contact measurements of waves outside said diffusive medium to generate a tomographic image.
Claims26
A real time Diffusive Optical Tomographic (DOT) imaging system for imaging of a biological tissue of a subject comprising:
- (a) an excitation light source
- for directing excitation light waves from the excitation light source into the biological tissue to cause an administered fluorescent imaging probe in the three-dimensional target region to emit fluorescent light, wherein the biological tissue of the subject has a volume V bounded by boundary S, and wherein the volume V is of arbitrary geometry;
- (b) a detector for detecting an intensity of the fluorescent light and the excitation light waves emitted from multiple points from the biological tissue by using non-contact measurements of the excitation light waves and the fluorescent light outside the biological tissue, where there is air between the detector and biological tissue;
- and
- (c) a computer processor for processing the detected intensity of fluorescent light and the detected intensity of the excitation light waves to generate a tomographic image indicating the quantity of fluorescent imaging probe in the three-dimensional target region within the subject;
- wherein the computer processor generates the tomographic image by modeling propagation of diffuse photon waves inside the volume V taking into account the boundary surface S and a modeling of the intensities at the detector located outside the biological tissue of the subject.
3 more elements
A method for real time Diffusive Optical Tomographic (DOT) imaging of a biological tissue of a subject comprising:
- (a) administering a fluorescent imaging probe to the subject for accumulation in a three-dimensional target region comprising the biological tissue, wherein the biological tissue of the subject has a volume V bounded by boundary S, and wherein the volume V is of arbitrary geometry;
- (b) directing excitation light waves into the biological tissue to cause the fluorescent imaging probe in the three-dimensional target region to emit fluorescent light, wherein the excitation light waves comprise at least one of the following:
- (i) intensity-modulated light with a characteristic period of modulation, (ii) wavelength-modulated light with a characteristic period of modulation, and (iii) time-resolved light pulses;
- (c) using a detector to detect an intensity of the fluorescent light and the excitation light waves emitted from multiple points from the biological tissue by using non-contact measurements of the excitation light waves and the fluorescent light outside the biological tissue, where there is air between the detector and biological tissue;
- and
- (d) processing the detected intensity of fluorescent light and the detected intensity of the excitation light waves to generate a tomographic image indicating the quantity of fluorescent imaging probe in the three-dimensional target region within the subject;
- wherein the tomographic image is generated by modeling propagation of diffuse photon waves inside the volume V taking into account the boundary surface S and a modeling of the intensities at the detector located outside the biological tissue of the subject.
4 more elements
A method for real time Diffusive Optical Tomographic (DOT) imaging of a biological tissue of a subject comprising:
- (a) administering a fluorescent imaging probe to the subject for accumulation in a three-dimensional target region comprising the biological tissue, wherein the biological tissue of the subject has a volume V bounded by boundary S, and wherein the volume V is of arbitrary geometry;
- (b) directing excitation light waves into the biological tissue to cause the fluorescent imaging probe in the three-dimensional target region to emit fluorescent light, wherein the excitation light waves comprise at least one of:
- (i) a single point of illumination, and (ii) a spatially modulated pattern of illumination;
- (c) using a detector to detect an intensity of the fluorescent light and the excitation light waves emitted from multiple points from the biological tissue by using non-contact measurements of the excitation light waves and the fluorescent light outside the biological tissue, where there is air between the detector and biological tissue;
- and
- (d) processing the detected intensity of fluorescent light and the detected intensity of the excitation light waves to generate a tomographic image indicating the quantity of fluorescent imaging probe in the three-dimensional target region within the subject;
- wherein the tomographic image is generated by modeling propagation of diffuse photon waves inside the volume V taking into account the boundary surface S and a modeling of the intensities at the detector located outside the biological tissue of the subject.
4 more elements
Dependencies are inferred from the claim text.