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US 8,946,475 B2Granted
Processes for preparing a polymeric compound
AssigneeCellceutix Corporation
InventorsRobert W. Kavash, Haizhong Tang, Carol Mulrooney, Dahui Liu
Life of this patent
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Abstract
The present invention provides methods for preparing a polymeric compound of Formula I: or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.
Claims22
A method for preparing a compound of Formula I:
- or pharmaceutically acceptable salt thereof, comprising:
- a) removing the Cbz groups from a compound of Formula II:
- or pharmaceutically acceptable salt thereof, under a hydrogen source chosen from H2 gas, formic acid, ammonium formate, and 1,4-cyclohexadiene, and a metal catalyst chosen from Pd/C, Pd black, Pd(OH)2, PdCl2, Raney Ni, a platinum catalyst, a rhodium catalyst, and a ruthenium catalyst to form the compound of Formula I, or pharmaceutically acceptable salt thereof;
- and
- b) optionally isolating the compound of Formula I, or pharmaceutically acceptable salt thereof.
2 more elements
A method for preparing a compound of formula I:
- or pharmaceutically acceptable salt thereof, comprising:
- a1) removing the Cbz groups from a compound of Formula II-1:
- or pharmaceutically acceptable salt thereof, under a hydrogen source chosen from H2 gas, formic acid, ammonium formate, and 1,4-cyclohexadiene, and a metal catalyst chosen from Pd/C, Pd black, Pd(OH)2, PdCl2, Raney Ni, a platinum catalyst, a rhodium catalyst, and a ruthenium catalyst, to form the compound of Formula I, or pharmaceutically acceptable salt thereof;
- and
- b1) optionally isolating the compound of Formula I, or pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.