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US 8,946,473 B2Granted
Methods of making L-ornithine phenyl acetate
AssigneeOcera Therapeutics, Inc.
InventorsKeith H. Anderson, Jim Behling, Christine Henderson Dougan, Stephen William Watt, Peter Manini, Attilia Figini
Life of this patent
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Abstract
Disclosed herein are processes for making L-ornithine phenyl acetate. The process may include, for example, inter-mixing a halide salt of L-ornithine with silver phenyl acetate. The process may also include forming a phenyl acetate salt in situ. The present application also relates to various compositions obtained from these processes, including crystalline forms.
Claims34
A process for making L-ornithine phenyl acetate salt comprising:
- preparing a solution of phenyl acetate salt by mixing a phenyl acetic acid and a base in a solvent;
- intermixing L-ornithine benzoate with the solution of phenyl acetate salt;
- and
- isolating a composition comprising L-ornithine phenyl acetate.
1 more element
A process for making L-ornithine phenyl acetate salt comprising:
- intermixing an L-ornithine salt, silver phenyl acetate and a solvent to form a solution;
- and
- isolating a composition comprising L-ornithine phenyl acetate from said solution.
Dependencies are inferred from the claim text.