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US 8,946,455 B2Granted
Semi-synthetic small molecules for the treatment parasitic disease
AssigneeThe Regents of the University of California
InventorsRoger Linington, Gabriel Navarro, Khanitha Pudhom, James McKerrow
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Abstract
Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fugally-derived natural product merulin A for the treatment of African Sleeping Sickness.
Claims4
A compound of formula
- wherein R is —OCORa and Ra is selected from straight or branched C2-C8 alkyl, C3-C6 cycloalkyl or cycloalkyl C1-C6 alkyl, heterocycloalkyl, or heterocycloalkyl C1 to C6 alkyl, aryl C1 to C6 alkyl, heteroaryl or heteroaryl C1 to C6 alkyl or a salt thereof.
Dependencies are inferred from the claim text.