Lipoic acid acylated salicylate derivatives and their uses

A compound of Formula I:

• or a pharmaceutically acceptable salt, hydrate, solvate, enantiomer, or stereoisomer thereof;
• wherein
• R1, R2, R3, and R4 are each independently selected from the group consisting of H, Cl, F, CN, NH2, —NH(C1-C3 alkyl), —N(C1-C3 alkyl)2, —NH(C(O)C1-C3 alkyl), —N(C(O)C1-C3 alkyl)2, —C(O)H, —C(O)C1-C3 alkyl, —C(O)OC1-C3 alkyl, —C(O)NH2, —C(O)NH(C1-C3 alkyl), —C(O)N(C1-C3 alkyl)2, —C1-C3 alkyl, —O—C1-C3 alkyl, —S(O)C1-C3 alkyl, and —S(O)2C1-C3 alkyl;
• W1 and W2 are each independently S, NR, or W1 and W2 can be taken together can form an imidazolidine or piperazine group;
• each symbol ----- represents an optional bond, which when present between the phenolic oxygen and the methylene containing substituent a, requires that Q is null, or when present between substituent a and the carbon of the methylene containing substituent a, requires that Q not be null;
• each a, b, c, and d is independently —H, -D, —C1-C3 alkyl, —O—C1-C3 alkyl, —C(O)OR, —O—Z, or benzyl, or two of a, b, c, and d can be taken together, along with the single carbon to which they are bound, to form a cycloalkyl or heterocycle;
• each n, o, p, and q is independently 0, 1, or 2;
• each L is independently —O—, —S—, —S(O)—, —S(O)2—, —S—S—,-(C1-C6alkyl)-
• wherein the representation of L is not limited directionally left to right as is depicted, rather either the left side or the right side of L can be bound to the W1 side of the compound of Formula I;
• each g is independently 2, 3 or 4;
• each h is independently 1, 2, 3 or 4;
• m is 0, 1, 2, or 3;
• if m is more than 1, then L can be the same or different;
• each R5 is independently H or C1-C6 alkyl, or both R5 groups, when taken together with the nitrogen to which they are attached, can form a heterocycle;
• each R6 is independently e, H, or straight or branched C1-C10 alkyl which can be optionally substituted with OH, NH2, CO2R, CONH2, phenyl, C6H4OH, imidazole or arginine;
• each e is independently H or any one of the side chains of the naturally occurring amino acids;
• each Z is independently H, or
• with the proviso that there is at least one
• in the compound;
• each t is independently 0 or 1;
• Q is null, C(O)CH3, Z,
• W3 is null, —O—, or —N(R)—;
• each R is independently H, —C(O)—C1-C3 alkyl, or straight or branched C1-C4 alkyl optionally substituted with or halogen;
• and
• T is H, C(O)CH3, or Z.