Amide compounds, compositions and uses thereof

A compound having a formula 1:

• wherein
• each of A, B, and W are independently selected from CR4;
• X′ is N;
• L is —C(R2aR2b)—;
• R1 is selected from substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, hydroxy C1-C4 alkyl, C3-C7 cycloalkyl-C1-C4 alkyl, or 4-7 membered heterocycloalkyl-C1-C4 alkyl;
• each of R2a and R2b is independently selected from hydrogen, C1-C4 alkyl, or hydroxy C1-C4 alkyl;
• R3 is OR3a, CN, COR3a, COOR3a, SOR3a, CONR3aR3b, SONR3aR3b, or SO2NR3aR3b;
• R3a is substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R3b is H, substituted or unsubstituted C1-C6 alkyl;
• or R3a and R3b join together to form a cycloheteroalkyl ring of 3-7 atoms;
• each R4 is independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, substituted or unsubstituted amino, substituted or unsubstituted arylalkyl, sulfo, substituted sulfo, substituted sulfonyl, substituted sulfinyl, substituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted arylsulfonyl, azido, substituted or unsubstituted carbamoyl, carboxyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted dialkylamino, halo, nitro, and thiol;
• each R4b is independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkylthio, substituted or unsubstituted alkoxy, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, substituted or unsubstituted arylalkyloxy, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, sulfo, substituted sulfo, substituted sulfonyl, substituted sulfinyl, substituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted arylsulfonyl, azido, substituted or unsubstituted carbamoyl, carboxyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted dialkylamino, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thiol;
• and subscript m′ is selected from 0-4;
• provided that
• i) when R3 is CO2Me, or OR3a;
• then R1 is other than unsubstituted phenyl;
• and
• ii) when R1 is 5-6 membered heterocycloalkylmethyl, and R3 is CO2Me;
• then R4b is other than Cl or 4-F;
• or a pharmaceutically acceptable salt, N-oxide, stereoisomer or tautomer thereof.